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Table 1: Patient characteristics of randomised controlled trials
| Trial, Year | Patient Numbers | Breast cancer characteristics | Patient Age / Menopausal status |
|---|---|---|---|
| Chetty, 200053 | 466 | Operable breast cancer, tumour size ≤4cm | Median age: 54yrs |
| Fisher, 200222 | 1665 | Primary operable breast cancer, clinically node-negative and positive | NR |
| Kodama, 200620 | 514 | Breast cancer (T1-3, N0, N1a, N1b) |
Level I dissection vs. level III dissection Mean age: 51.6yrs vs. 50.6yrs Menopausal status |
| Louis-Sylvestre, 200421 | 658 | Invasive breast cancer, tumour size <3cm, clinically node- negative |
Axillary radiotherapy vs. axillary dissection Mean age: 50.6yrs vs. 52yrs Menopausal statuspremenopausal: |
| Martelli, 200524 | 219 | Early breast cancer, clinically negative axillary nodes, tumour size ≤2cm | Age 65 to 80 years; median 70yrs |
| Morgan, 200254 | 76 | Operable (stage I or II) primary breast cancer, tumour grade III, with at least one node involved | NR |
|
Overgaard 200725; Nielson, 200656, 57 |
3083 | High-risk breast cancer patients defined as patients who were node positive and/or a T3 or T4 tumour and/or skin or deep fascia invasion | Pre- and postmenopausal |
| Rudenstam, 200623 | 473 | Clinically node-negative operable breast cancer, tumour size: <2cm 56%, >2cm 42% | Age ≥60yrs: median 74yrs (60-91yrs) |
| Rutqvist, 200658 | 1226 | High-risk breast cancer patients, node-positive disease or a tumour size >30mm | Menopausal status: premenopausal 547pts postmenopausal 679pts |
| Tominaga, 200319 | 1209 | Breast cancer stage II (T2 N0 or T2 N1a, excluding N1b) |
Age:<40yrs: 115pts, 41-50yrs: 447 pts, Menopausal status: premenopausal 567ptspostmenopausal 620pts |
| Veronesi, 200555 | 435 | Breast cancer with no palpable axillary nodes, tumour size ≤1.2cm (<0.5cm 13.1%, 0.6-1cm 61.4%, 1.1-1.2cm 16.3%, 1.2-1.5cm 9.2%) | Age >45yrs (<55yrs 40.2%, 56-65yrs 44.6%, >65yrs 15.2%) |
Note: NR = not reported
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