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One randomised controlled trial investigating the use of hypofractionated radiotherapy for early breast cancer is ongoing:
- FAST Trial** (UK) compares 28.5 Gy or 30 Gy in five once-weekly fractions of 5.7 Gy or 6.0 Gy respectively, with a control dose of 50Gy in 25 fractions over 5 weeks, delivered with three dimensional dose-compensated whole-breast radiotherapy.
**First results of the FAST Trial have indicated the 28.5 Gy in 5 fractions schedule was comparable to the schedule 50 Gy in 25 fractions, and milder than the 30 Gy in 5 fractions schedule, for adverse effects on breast appearance.21
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